Gene information
Official symbol HFE
Official full name homeostatic iron regulator
Gene type protein-coding gene
Chromosome6p22.2
Alias symbolHLA-H; HFE1
Gene familyC1-set domain containing
Resources
Entrez Gene 3077
HGNC HGNC:4886
Ensembl ENSG00000010704
Vega OTTHUMG00000016348
UCSC uc003nfx.2
GO terms: 98 records
GO Description Category LogP Number of genes Detail
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0002577 regulation of antigen processing and presentation GO Biological Processes -2.79007403 3 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002695 negative regulation of leukocyte activation GO Biological Processes -9.84552767 31 More
GO:0002703 regulation of leukocyte mediated immunity GO Biological Processes -18.0432682 27 More
GO:0002704 negative regulation of leukocyte mediated immunity GO Biological Processes -2.91912787 5 More
GO:0002718 regulation of cytokine production involved in immune response GO Biological Processes -15.9157324 18 More
GO:0002719 negative regulation of cytokine production involved in immune response GO Biological Processes -9.55471636 12 More
GO:0002724 regulation of T cell cytokine production GO Biological Processes -9.29772341 9 More
GO:0002791 regulation of peptide secretion GO Biological Processes -16.5189310 23 More
GO:0002793 positive regulation of peptide secretion GO Biological Processes -7.26567394 18 More
GO:0002820 negative regulation of adaptive immune response GO Biological Processes -3.17098953 5 More
GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -3.34951384 5 More
GO:0005769 early endosome GO Cellular Components -6.25251045 19 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -8.77828157 29 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010038 response to metal ion GO Biological Processes -20.5090881 61 More
GO:0010039 response to iron ion GO Biological Processes -3.60825621 7 More
GO:0010469 regulation of signaling receptor activity GO Biological Processes -13.5880476 20 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO Biological Processes -7.11509809 13 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0030001 metal ion transport GO Biological Processes -7.54203733 26 More
GO:0030100 regulation of endocytosis GO Biological Processes -14.0757782 22 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030509 BMP signaling pathway GO Biological Processes -5.83413377 15 More
GO:0031330 negative regulation of cellular catabolic process GO Biological Processes -6.88355184 32 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0032091 negative regulation of protein binding GO Biological Processes -7.69848876 11 More
GO:0032092 positive regulation of protein binding GO Biological Processes -4.19203093 7 More
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO Biological Processes -2.20869648 6 More
GO:0042445 hormone metabolic process GO Biological Processes -9.53279610 17 More
GO:0042446 hormone biosynthetic process GO Biological Processes -2.77870822 4 More
GO:0042594 response to starvation GO Biological Processes -5.43370462 24 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043393 regulation of protein binding GO Biological Processes -7.80142307 15 More
GO:0045177 apical part of cell GO Cellular Components -8.17813885 46 More
GO:0045178 basal part of cell GO Cellular Components -4.63395469 13 More
GO:0045807 positive regulation of endocytosis GO Biological Processes -11.0143833 14 More
GO:0046634 regulation of alpha-beta T cell activation GO Biological Processes -7.20313216 11 More
GO:0046883 regulation of hormone secretion GO Biological Processes -20.4338227 29 More
GO:0046887 positive regulation of hormone secretion GO Biological Processes -9.61661717 24 More
GO:0048259 regulation of receptor-mediated endocytosis GO Biological Processes -11.3903749 15 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0048871 multicellular organismal homeostasis GO Biological Processes -14.5562171 53 More
GO:0050777 negative regulation of immune response GO Biological Processes -11.1440698 32 More
GO:0050801 ion homeostasis GO Biological Processes -12.0812968 60 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050868 negative regulation of T cell activation GO Biological Processes -5.59075646 10 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051098 regulation of binding GO Biological Processes -15.8856010 30 More
GO:0051099 positive regulation of binding GO Biological Processes -11.1715489 31 More
GO:0051100 negative regulation of binding GO Biological Processes -8.85516089 15 More
GO:0051250 negative regulation of lymphocyte activation GO Biological Processes -7.76846228 25 More
GO:0055082 cellular chemical homeostasis GO Biological Processes -17.6289728 71 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation GO Biological Processes -7.52187520 15 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0061136 regulation of proteasomal protein catabolic process GO Biological Processes -2.09695987 7 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071241 cellular response to inorganic substance GO Biological Processes -4.23170629 23 More
GO:0071248 cellular response to metal ion GO Biological Processes -4.26641514 21 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071772 response to BMP GO Biological Processes -7.7216264 19 More
GO:0071773 cellular response to BMP stimulus GO Biological Processes -7.7216264 19 More
GO:0090087 regulation of peptide transport GO Biological Processes -16.3568662 23 More
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -13.1150464 44 More
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -10.5573443 25 More
GO:0090276 regulation of peptide hormone secretion GO Biological Processes -16.6841590 23 More
GO:0090277 positive regulation of peptide hormone secretion GO Biological Processes -6.66447400 17 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098655 cation transmembrane transport GO Biological Processes -3.98966777 20 More
GO:0098657 import into cell GO Biological Processes -2.13294972 7 More
GO:0098659 inorganic cation import across plasma membrane GO Biological Processes -1.65407437 9 More
GO:0098660 inorganic ion transmembrane transport GO Biological Processes -4.47276690 21 More
GO:0098662 inorganic cation transmembrane transport GO Biological Processes -4.65654157 20 More
GO:0098739 import across plasma membrane GO Biological Processes -1.45340005 5 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0098802 plasma membrane signaling receptor complex GO Cellular Components -6.47096721 17 More
GO:0099587 inorganic ion import across plasma membrane GO Biological Processes -1.65407437 9 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903038 negative regulation of leukocyte cell-cell adhesion GO Biological Processes -10.2281373 27 More
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO Biological Processes -2.26022124 8 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:2000008 regulation of protein localization to cell surface GO Biological Processes -2.85651055 4 More
GO:2000058 regulation of ubiquitin-dependent protein catabolic process GO Biological Processes -2.40864048 7 More
GO:2000272 negative regulation of signaling receptor activity GO Biological Processes -7.12747015 9 More
GO:2000273 positive regulation of signaling receptor activity GO Biological Processes -8.61037442 14 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
adalimumab PharmGKB 27115882 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NM_000410.4:c.845G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Tuomainen TP et al. Circulation. 1999
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